{"id":27,"date":"2023-02-08T21:20:09","date_gmt":"2023-02-08T21:20:09","guid":{"rendered":"https:\/\/biodesign.qa.rtd.asu.edu\/cellular-evolution\/?page_id=27"},"modified":"2023-03-28T21:19:54","modified_gmt":"2023-03-28T21:19:54","slug":"research","status":"publish","type":"page","link":"https:\/\/biodesign.asu.edu\/cellular-evolution\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<div id=\"unityblocks-hero\" class=\"wp-block-unityblocks-hero hide-content\" data-herotype=\"heading-hero\" data-image=\"{&quot;url&quot;:&quot;https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/03\/cellular-evolution-research-hero-1920.jpg&quot;,&quot;altText&quot;:&quot;Young scientist in lab gear holds a pipette at a lab table&quot;,&quot;cssClass&quot;:[],&quot;size&quot;:&quot;medium&quot;}\" data-subtitle=\"{&quot;text&quot;:&quot;&quot;,&quot;highlightColor&quot;:&quot;white&quot;,&quot;maxWidth&quot;:&quot;&quot;,&quot;cssClass&quot;:[]}\" data-title=\"{&quot;text&quot;:&quot;Biological Integration Institute for Mechanisms of Cellular Evolution&quot;,&quot;highlightColor&quot;:&quot;gold&quot;,&quot;maxWidth&quot;:&quot;&quot;,&quot;cssClass&quot;:[]}\" data-contents=\"[{&quot;text&quot;:&quot;&quot;,&quot;maxWidth&quot;:&quot;&quot;,&quot;cssClass&quot;:[],&quot;highlightColor&quot;:&quot;white&quot;}]\" data-contentscolor=\"white\"><\/div>\n\n\n<div class=\"wp-bootstrap-blocks-container container mb-0 my-2 my-md-6 my-xl-10\">\n\t\n<div class=\"wp-bootstrap-blocks-row row justify-content-between\">\n\t\n\n<div class=\"col-12 col-md-3\">\n\t\t\t\n\n<div class=\"wp-block-group mb-4 is-layout-constrained wp-block-group-is-layout-constrained\"><div aria-controls=\"sidebar\" aria-expanded=\"false\" class=\"sidebar-toggler\" data-target=\"#sidebar\" data-toggle=\"collapse\"><p>Select Section <\/p><span class=\"fas fa-chevron-up\" \/><\/div><nav class=\"sidebar collapse\" id=\"sidebar\" aria-label=\"Secondary\"> <div class=\"nav-link-container\"><a id=\"menu-item-57\" href=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-home nav-link\">Overview<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-41\" href=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/research\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">Research<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-40\" href=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/publications\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">Publications<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-39\" href=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/training-and-outreach\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">Training and Outreach<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-38\" href=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/people\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">People<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-37\" href=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/jobs\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">Jobs<\/a><\/div><\/li>\n<\/nav>\n<\/div>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-8\">\n\t\t\t\n<div class=\"wp-bootstrap-blocks-row row\">\n\t\n\n<div class=\"col-12 col-md-7\">\n\t\t\t\n\n<h2 class=\"mt-0 wp-block-heading\">Research<\/h2>\n\n\t<\/div>\n\n<\/div>\n\n\n\n<p>Our ongoing research efforts are exploring the biology and internal anatomy of cells, the relationships between cell traits and cell size, complex molecular machines as they appear across the Tree of Life, and cellular evolution in action.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large mt-6\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"512\" src=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/phylogenetic-census-of-cellular-traits-1584-1024x512.jpg\" alt=\"\" class=\"wp-image-97\" srcset=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/phylogenetic-census-of-cellular-traits-1584-1024x512.jpg 1024w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/phylogenetic-census-of-cellular-traits-1584-300x150.jpg 300w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/phylogenetic-census-of-cellular-traits-1584-768x384.jpg 768w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/phylogenetic-census-of-cellular-traits-1584-1536x768.jpg 1536w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/phylogenetic-census-of-cellular-traits-1584.jpg 1584w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Phylogenetic census of cellular traits and their costs<\/h3>\n\n\n\n<p>This project will construct an atlas of the biology of cells through a range of new investigative techniques, including the exploration of the internal anatomy of cells through 3D reconstructions. Comparative genomics, spatial proteomics, microscopy and bioenergetic analyses will be used to further assess the biological costs of constructing and operating an array of cellular features.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large mt-4\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"512\" src=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolution-theory-for-cellular-traits-1584-1024x512.jpg\" alt=\"\" class=\"wp-image-99\" srcset=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolution-theory-for-cellular-traits-1584-1024x512.jpg 1024w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolution-theory-for-cellular-traits-1584-300x150.jpg 300w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolution-theory-for-cellular-traits-1584-768x384.jpg 768w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolution-theory-for-cellular-traits-1584-1536x768.jpg 1536w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolution-theory-for-cellular-traits-1584.jpg 1584w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Evolutionary theory for cellular traits<\/h3>\n\n\n\n<p>Cellular attributes commonly follow systematic, quantitative relationships with cell size that transcend species boundaries, leading to patterns called cell biological scaling laws. This project investigates how these relationships apply across different forms of cellular life \u2014 such as how factors like cell growth rates or the numbers of mitochondria inside cells scale with cell size \u2014 and seeks to understand the mechanisms underlying the patterns from first principles.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large mt-4\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"512\" src=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolutionary-divergence-of-complex-molecular-machines-1584-1024x512.jpg\" alt=\"\" class=\"wp-image-100\" srcset=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolutionary-divergence-of-complex-molecular-machines-1584-1024x512.jpg 1024w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolutionary-divergence-of-complex-molecular-machines-1584-300x150.jpg 300w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolutionary-divergence-of-complex-molecular-machines-1584-768x384.jpg 768w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolutionary-divergence-of-complex-molecular-machines-1584-1536x768.jpg 1536w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/evolutionary-divergence-of-complex-molecular-machines-1584.jpg 1584w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Evolutionary divergence of complex molecular machines<\/h3>\n\n\n\n<p>One of the great mysteries of evolutionary cell biology concerns the mechanisms by which complex molecular machines with highly conserved functions can diverge structurally across the Tree of Life. This investigation considers two of the central molecular machines contained within all cells: ATP synthase, the machine that produces ATP by transporting protons across membranes; and ribosomes, which translate all messenger RNAs into proteins.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large mt-4\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"512\" src=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/molecular-underpinnings-of-cellular-evolution-1584-1024x512.jpg\" alt=\"\" class=\"wp-image-101\" srcset=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/molecular-underpinnings-of-cellular-evolution-1584-1024x512.jpg 1024w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/molecular-underpinnings-of-cellular-evolution-1584-300x150.jpg 300w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/molecular-underpinnings-of-cellular-evolution-1584-768x384.jpg 768w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/molecular-underpinnings-of-cellular-evolution-1584-1536x768.jpg 1536w, https:\/\/biodesign.asu.edu\/cellular-evolution\/wp-content\/uploads\/sites\/23\/2023\/02\/molecular-underpinnings-of-cellular-evolution-1584.jpg 1584w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Molecular underpinnings of cellular evolution<\/h3>\n\n\n\n<p>This project focuses on evolution in action through experimental lab studies with a broad range of unicellular organisms. Among other things, the work will utilize systems that enable \u201cbarcoding\u201d of different microbial strains so that novel mutations and subtle changes in cell physiology can be tracked through time as the cells respond to variables like temperature, population size and food availability.<\/p>\n\n\t<\/div>\n\n<\/div>\n\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"uds_featured_image":null,"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research - Institute for Mechanisms of Cellular Evolution<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biodesign.asu.edu\/cellular-evolution\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research - 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