Professor, Biodesign Center for Immunotherapy, Vaccines and Virotherapy
Associate Faculty, Biodesign Center for Applied Structural Discovery
Brenda Hogue is a molecular biologist who studies how viruses replicate and assemble and how they impact host cells, ultimately contributing to disease. Her goal is to understand the molecular biology of a virus in order to identify targets for antiviral therapeutics and vaccine development.
The Hogue lab uses state-of-the-art molecular approaches and bioimaging (confocal and electron microscopy) to understand the mechanistic processes of virus assembly and replication. Their viral protein and virus structure studies employ x-ray crystallography and a new ultrafast, pulsed x-ray free-electron laserat the SLAC National Accelerator Laboratory at Stanford.
Hogue’s research focuses on protein structure-function studies of viruses that assemble at intracellular membranes, mainly coronaviruses. Her findings are applied to development of vaccine platforms against the severe acute respiratory (SARS) and recently emerged Middle East respiratory (MERS) coronaviruses.