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  1. Arndt WD, Cotsmire S, Trainor K, Harrington H, Hauns K, Kibler KV, Huynh TP, Jacobs BL. Evasion of the Innate Immune Type I Interferon System by Monkeypox Virus. J Virol. 2015 Oct;89(20):10489-99. doi: 10.1128/JVI.00304-15. Epub 2015 Aug 5.

  2. Ye Y, Hauns K, Langland JO, Jacobs BL, Hogue BG. Mouse hepatitis coronavirus A59 nucleocapsid protein is a type I interferon antagonist. J Virol. 2007 Mar;81(6):2554-63. Epub 2006 Dec 20.
    PMID: 17182678 Free PMC Article

  3. McAfee MS, Huynh TP, Johnson JL, Jacobs BL, Blattman JN. Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity. Virology. 2015 Oct;484:153-62. doi: 10.1016/j.virol.2015.05.021. Epub 2015 Jun 20.

  4. Arndt W, Mitnik C, Denzler KL, White S, Waters R, Jacobs BL, Rochon Y, Olson VA, Damon IK, Langland JO.. In vitro characterization of a nineteenth-century therapy for smallpox.. PLoS One. 2012;7(3):e32610. doi: 10.1371 (2012).

  5. White SD, Jacobs BL.. The amino terminus of the vaccinia virus E3 protein is necessary to inhibit the interferon response.. J. Virology (2012).


  1. Denzler KL, Babas T, Rippeon A, Huynh T, Fukushima N, Rhodes L, Silvera PM, Jacobs BL.. Attenuated NYCBH vaccinia virus deleted for the E3L gene confers partial protection against lethal monkeypox virus disease in cynomolgus macaques.. Vaccine (2011).

  2. Denzler KL, Rice AD, MacNeill AL, Fukushima N, Lindsey SF, Wallace G, Burrage AM, Smith AJ, Manning BR, Swetnam DM, Gray SA, Moyer RW, Jacobs BL.. The NYCBH vaccinia virus deleted for the innate immune evasion gene, E3L, protects rabbits against lethal challenge by rabbitpox virus.. Vaccine (2011).

  3. Denzler KL, Schriewer J, Parker S, Werner C, Hartzler H, Hembrador E, Huynh T, Holechek S, Buller RM, Jacobs BL.. The attenuated NYCBH vaccinia virus deleted for the immune evasion gene, E3L, completely protects mice against heterologous challenge with ectromelia virus.. Vaccine (2011).

  4. Jancovich JK, Jacobs BL.. Innate immune evasion mediated by the Ambystoma tigrinum virus eukaryotic translation initiation factor 2alpha homologue.. J. Virology (2011).

  5. Kibler KV, Gomez CE, Perdiguero B, Wong S, Huynh T, Holechek S, Arndt W, Jimenez V, Gonzalez-Sanz R, Denzler K, Haddad EK, Wagner R, Sékaly RP, Tartaglia J, Pantaleo G, Jacobs BL, Esteban M.. Improved NYVAC-based vaccine vectors.. PLoS One (2011).

  6. White SD, Conwell K, Langland JO, Jacobs BL.. Use of a negative selectable marker for rapid selection of recombinant vaccinia virus.. Biotechniques (2011).


  1. Jacobs BL, Langland JO, Kibler KV, Denzler KL, White SD, Holechek SA, Wong S, Huynh T, Baskin CR.. Vaccinia virus vaccines: past, present and future.. Antiviral Res. (2009).

  2. Zhang P, Langland JO, Jacobs BL, Samuel CE. Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L.. J Virol. (2009).


  1. Y Ye, K Hauns, J Langland, Bertram Jacobs, B Hogue. Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein is a Type I Interferon Antagonist. J Virol (2007).


  1. J Langland, J Kash, V Carter, M Thomas, M Katze, Bertram Jacobs. Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins. J Virol (2006).

  2. Jeffrey Langland, Jason Cameron, Michael Heck, James Jancovich, Bertram Jacobs. Inhibition of PKR by RNA and DNA viruses. Virus Research (2006).

  3. Langland, J, Cameron, J, Heck, M, Jancovich, J, Jacobs, Bertram. Inhibition of PKR by RNA and DNA viruses. Virus Res (2006).


  1. J Jancovich, E Davidson, N Parameswaran, J Mao, V Chinchar, J Collins, Bertram Jacobs, A Storfer. Evidence for emergence of an amphibian iridoviral disease because of human-enhanced spread. Mol Ecol (2005).

  2. T Brandt, M Heck, S Vijaysri, G Jentarra, J Cameron, Bertram Jacobs. The N-terminal domain of the vaccinia virus E3L-protein is required for neurovirulence, but not induction of a protective immune response. Virology (2005).


  1. C Auch, R Saha, F Sheikh, X Liu, Bertram Jacobs, K Pahan. Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia. FEBS Lett (2004).

  2. J Langland, Bertram Jacobs. Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. Virology (2004).

  3. K Kibler, A Miyazato, V Yedavalli, A Dayton, Bertram Jacobs, G Dapolito, S Kim, K Jeang. Polyarginine Inhibits gp160 Processing by Furin and Suppresses Productive Human Immunodeficiency Virus Type 1 Infection. J Biol Chem (2004).


  1. J Jancovich, J Collind, Bertram Jacobs, J Mao, V Chinchar, C Wyatt, S Case, Sudhir Kumar, G Valente, S Subramanian, E Davidson. Genomic Sequence of a Ranavirus (Family Iridoviridae) Associated with Salamander Mortalities in North America. Virology (2003).

  2. J Jancovich, James Collins, Bertram Jacobs, J Mao, V Chinchar, C Wyatt, S Case, S Kumar, G Valente, S Subramanian, E Davidson. Genomic sequence of a ranavirus (family Iridoviridae) associated with salamander mortalities in North America. Virology (2003).

  3. J Langland, P Kao, Bertram Jacobs. Regulation of IL-2 gene expression and nuclear factor-90 translocation in vaccinia virus-infected cells. J Interferon Cytokine Res (2003).

  4. S Vijaysri, L Talasela, A Mercer, C McInnes, Bertram Jacobs, J Langland. The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo. Virology (2003).

  5. Y Kim, M Muralinath, T Brandt, M Pearcy, K Hauns, K Lowenhaupt, Bertram Jacobs, A Rich. A role for Z-DNA binding in vaccinia virus pathogenesis. Proc Natl Acad Sci U S A (2003).


  1. J Langland, Bertram Jacobs. The Role of the PKR-Inhibitory Genes, E3L and K3L, in Determining Vaccinia Virus Host Range. Virology (2002).

  2. Y He, H Nakao, S Tan, S Polyak, P Neddermann, S Vijaysri, Bertram Jacobs, M Katze. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol (2002).

  3. Y Xiang, R Condit, S Vijaysri, Bertram Jacobs, B Williams, R Silverman. Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. J Virol (2002).


  1. T Brandt, Bertram Jacobs. Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model. J Virol (2001).

  2. Y He, S Tan, S Tareen, Bertram Jacobs, S Vijaysri, J Langland, M Katze. Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A. J Virol (2001).