{"id":6,"date":"2022-01-12T18:23:36","date_gmt":"2022-01-12T18:23:36","guid":{"rendered":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/?page_id=6"},"modified":"2023-02-11T00:00:28","modified_gmt":"2023-02-11T00:00:28","slug":"research","status":"publish","type":"page","link":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<div id=\"unityblocks-hero\" class=\"wp-block-unityblocks-hero\" data-herotype=\"heading-hero\" data-image=\"{&quot;url&quot;:&quot;https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-content\/uploads\/sites\/6\/2022\/02\/ASD_WebBanner-1920-512.jpg&quot;,&quot;altText&quot;:&quot;&quot;,&quot;cssClass&quot;:[],&quot;size&quot;:&quot;medium&quot;}\" data-subtitle=\"{&quot;text&quot;:&quot;&quot;,&quot;highlightColor&quot;:&quot;white&quot;,&quot;maxWidth&quot;:&quot;&quot;,&quot;cssClass&quot;:[]}\" data-title=\"{&quot;text&quot;:&quot;Center for Applied Structural Discovery&quot;,&quot;highlightColor&quot;:&quot;gold&quot;,&quot;maxWidth&quot;:&quot;&quot;,&quot;cssClass&quot;:[]}\" data-contents=\"[{&quot;text&quot;:&quot;&quot;,&quot;maxWidth&quot;:&quot;&quot;,&quot;cssClass&quot;:[],&quot;highlightColor&quot;:&quot;white&quot;}]\" data-contentscolor=\"white\"><\/div>\n\n\n<div class=\"wp-bootstrap-blocks-container container mb-0\">\n\t\n<div class=\"wp-bootstrap-blocks-row row mt-4 mb-5\">\n\t\n\n<div class=\"col-12\">\n\t\t\t\n<div class=\"yoast-breadcrumbs\"><span><span><a href=\"https:\/\/biodesign.asu.edu\/our-centers\/\">Our Centers<\/a><\/span> \/ <span><a href=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/\">Applied Structural Discovery<\/a><\/span> \/ <span class=\"breadcrumb_last\" aria-current=\"page\">Research<\/span><\/span><\/div>\n\t<\/div>\n\n<\/div>\n\n\n<div class=\"wp-bootstrap-blocks-row row justify-content-between\">\n\t\n\n<div class=\"col-12 col-md-3 mb-6\">\n\t\t\t\n<div aria-controls=\"sidebar-applied-structural-discovery\" aria-expanded=\"false\" class=\"sidebar-toggler\" data-target=\"#sidebar-applied-structural-discovery\" data-toggle=\"collapse\"><p>Select Section <\/p><span class=\"fas fa-chevron-up\" \/><\/div><nav class=\"sidebar collapse\" id=\"sidebar-applied-structural-discovery\" aria-label=\"Secondary\"> <div class=\"nav-link-container\"><a id=\"menu-item-69\" href=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-home nav-link\">Overview<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-35\" href=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">Research<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-34\" href=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/team\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">Team<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-33\" href=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/technology\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">Technology<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-97\" href=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/news\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">News<\/a><\/div><\/li>\n <div class=\"nav-link-container\"><a id=\"menu-item-31\" href=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/opportunities\/\" class=\"menu-item menu-item-type-post_type menu-item-object-page nav-link\">Opportunities<\/a><\/div><\/li>\n<\/nav>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-8\">\n\t\t\t\n\n<h2 class=\"mt-0 wp-block-heading\">Research<\/h2>\n\n\n\n<p>Our research center is in the Biodesign Institute at Arizona State University. Its research complements the institute\u2019s mission to overcome complex global challenges by unlocking life\u2019s important secrets to create knowledge for improving human health, security and sustainability.&nbsp;<\/p>\n\n\n\n<h3 class=\"mt-6 wp-block-heading\"><strong>Femtosecond nano-crystallography of membrane proteins<\/strong>&nbsp;<\/h3>\n\n\n\n<p>Femtosecond pulses of X-ray free electron lasers are used to investigate the structure of membrane proteins. The project aims to develop the method of femtosecond crystallography for the structure determination of membrane proteins, where X-ray structure analysis is based on hundreds of thousands of X-ray diffraction patterns from a stream of fully hydrated nano\/microcrystals of membrane protein crystals. This project aims to open an exciting new avenue for membrane protein crystallography, where hundreds of thousands of diffraction patterns can be collected in a few minutes from fully hydrated micro\/nano crystals in their native conditions\u202fat room temperature, using X-ray laser pulses that are so short that no X-ray damage occurs during data collection. This method will be used to solve novel X-ray structures of membrane proteins.&nbsp;<\/p>\n\n\n\n<h3 class=\"mt-6 wp-block-heading\"><strong>Center for membrane proteins in infectious diseases <\/strong>&nbsp;<\/h3>\n\n\n\n<p>MPID is a PSI:Biology center investigating the structures of viral, bacterial and human membrane proteins involved in pathogenesis.\u202fUnder the leadership of the principal investigator, Petra Fromme, the MPID Center is trying to use the biological theme of membrane proteins in infectious diseases as the basis for the determination of novel membrane protein structures and to develop new technologies for high throughput membrane protein expression, isolation, functional characterization, crystallization\u202fand structure determination.&nbsp;<\/p>\n\n\n\n<p>The MPID Center targets membrane proteins of important viral and bacterial pathogens, their infectious pathways, and molecules involved in host defense against the pathogens. The structural\u202fdetermination of each of the targets may provide important clues for the understanding of the infectious disease pathways and can therefore form the basis for the treatment and prevention of infectious diseases.&nbsp;<\/p>\n\n\n\n<h3 class=\"mt-6 wp-block-heading\"><strong>Biology with X-ray lasers <\/strong>&nbsp;<\/h3>\n\n\n\n<p>BioXFEL is a Science and Technology center using X-ray lasers to image biomolecular machines in motion. X-ray lasers provide snapshots of\u202funprecedented clarity depicting the building blocks of life. The motions and arrangements of these blocks underlie all biological functions. The mission of BioXFEL is:&nbsp;<\/p>\n\n\n\n<ul class=\"uds-list\">\n<li>To use X-ray lasers, to watch biomolecular machines in operation, the better to understand how life works at the molecular level.&nbsp;<\/li>\n\n\n\n<li>To understand how these molecular machines support life on Earth.&nbsp;<\/li>\n\n\n\n<li>To invent, discover, develop and provide new tools and training to bring X-ray laser technology to the wider scientific community&nbsp;<\/li>\n<\/ul>\n\n\t<\/div>\n\n<\/div>\n\n<\/div>\n\n\n<section class=\"uds-section media-file inner-bg-none text-white gl-gray-7\" style=\"background: url(https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-content\/uploads\/sites\/6\/2022\/02\/Applied-Structural-Discovery.jpg) center \/ cover no-repeat;\" >\n<div class=\"wp-bootstrap-blocks-container container mb-0\">\n\t\n\n<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\"><div class=\"wp-bootstrap-blocks-container container mb-0\">\n\t\n<div class=\"wp-bootstrap-blocks-row row justify-content-between my-6 my-xl-12\">\n\t\n\n<div class=\"col-12 col-md-8\">\n\t\t\t\n\n<h2 class=\"wp-block-heading\">Support the Biodesign Center for Applied Structural Discovery<\/h2>\n\n\n\n<p class=\"lead text-white\">Using revolutionary techniques to uncover fundamental biological processes and make visionary discoveries impacting bioenergy, enzyme catalysis and drug discovery.<\/p>\n\n\t<\/div>\n\n\n\n<div class=\"col-12 col-md-4 d-flex align-items-center justify-content-start justify-content-md-end\">\n\t\t\t\n\n\t<div class=\"uds-button \">\n\n\t\t\t\n\t\t\t<a href=\"https:\/\/www.asufoundation.org\/colleges-and-programs\/programs-and-centers\/biodesign-institute\/biodesign-center-for-applied-structural-discovery-CA110214.html\" class=\"btn  btn-gold \"   >Support<\/a>\n\t\n\t\t<\/div>\n\n\t<\/div>\n\n<\/div>\n\n<\/div>\n<\/div>\n\n<\/div>\n\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":8,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"uds_featured_image":null,"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research | Applied Structural Discovery | ASU Biodesign Institute<\/title>\n<meta name=\"description\" content=\"The center\u2019s research unlocks life\u2019s important secrets to create knowledge for improving human health, security and sustainability.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research | Applied Structural Discovery | ASU Biodesign Institute\" \/>\n<meta property=\"og:description\" content=\"The center\u2019s research unlocks life\u2019s important secrets to create knowledge for improving human health, security and sustainability.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/\" \/>\n<meta property=\"og:site_name\" content=\"Applied Structural Discovery\" \/>\n<meta property=\"article:modified_time\" content=\"2023-02-11T00:00:28+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/\",\"url\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/\",\"name\":\"Research | Applied Structural Discovery | ASU Biodesign Institute\",\"isPartOf\":{\"@id\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/#website\"},\"datePublished\":\"2022-01-12T18:23:36+00:00\",\"dateModified\":\"2023-02-11T00:00:28+00:00\",\"description\":\"The center\u2019s research unlocks life\u2019s important secrets to create knowledge for improving human health, security and sustainability.\",\"breadcrumb\":{\"@id\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Our Centers\",\"item\":\"https:\/\/biodesign.asu.edu\/our-centers\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Applied Structural Discovery\",\"item\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/#website\",\"url\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/\",\"name\":\"Applied Structural Discovery\",\"description\":\"Just another Biodesign Sites site\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research | Applied Structural Discovery | ASU Biodesign Institute","description":"The center\u2019s research unlocks life\u2019s important secrets to create knowledge for improving human health, security and sustainability.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/","og_locale":"en_US","og_type":"article","og_title":"Research | Applied Structural Discovery | ASU Biodesign Institute","og_description":"The center\u2019s research unlocks life\u2019s important secrets to create knowledge for improving human health, security and sustainability.","og_url":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/","og_site_name":"Applied Structural Discovery","article_modified_time":"2023-02-11T00:00:28+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/","url":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/","name":"Research | Applied Structural Discovery | ASU Biodesign Institute","isPartOf":{"@id":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/#website"},"datePublished":"2022-01-12T18:23:36+00:00","dateModified":"2023-02-11T00:00:28+00:00","description":"The center\u2019s research unlocks life\u2019s important secrets to create knowledge for improving human health, security and sustainability.","breadcrumb":{"@id":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/research\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Our Centers","item":"https:\/\/biodesign.asu.edu\/our-centers\/"},{"@type":"ListItem","position":2,"name":"Applied Structural Discovery","item":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/"},{"@type":"ListItem","position":3,"name":"Research"}]},{"@type":"WebSite","@id":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/#website","url":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/","name":"Applied Structural Discovery","description":"Just another Biodesign Sites site","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-json\/wp\/v2\/pages\/6"}],"collection":[{"href":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-json\/wp\/v2\/comments?post=6"}],"version-history":[{"count":0,"href":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-json\/wp\/v2\/pages\/6\/revisions"}],"wp:attachment":[{"href":"https:\/\/biodesign.asu.edu\/applied-structural-discovery\/wp-json\/wp\/v2\/media?parent=6"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}