Breast Cancer Heterogeneity
Intra-tumor heterogeneity drives neoplastic progression. We hypothesize that the degree of intra-tumor heterogeneity in Ductal Carcinoma In Situ should predict which tumors are likely to become invasive and metastatic.
Genomic and micro-ecological heterogeneity drives neoplastic progression. We apply ecological theory to cancer biology.
Development of new methods to extract high quality sequencing data (Next generation sequencing) from small amounts of DNA extracted from Formalin-fixed, Paraffin-embedded samples.
Development of novel model organisms in cancer research
Currently we are working on:
Trichoplax adhaerens (Placozoa) is the simplest non-parasitic multicellular animal.
Tethya wilhelma (sponge) is a demosponge.
Macrostomum lignano (Flatworms) is a small free-living, marine flatworm within the phylum Platyhelminthes.