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  1. Yaron JR, Ambadapadi S, Zhang L, et al. Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection. Sci Rep. 2020;10(1):2371. Published 2020 Feb 11. doi:10.1038/s41598-020-59269-9

  2. Kwiecien JM, Dabrowski W, Dąbrowska-Bouta B, et al. Prolonged inflammation leads to ongoing damage after spinal cord injury. PLoS One. 2020;15(3):e0226584. Published 2020 Mar 19. doi:10.1371/journal.pone.0226584

  3. Yaron JR, Zhang L, Guo Q, et al. Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics. J Clin Med. 2020;9(4):972. Published 2020 Mar 31. doi:10.3390/jcm9040972

  4. Kwiecien JM, Zhang L, Yaron JR, et al. Local Serpin Treatment via Chitosan-Collagen Hydrogel after Spinal Cord Injury Reduces Tissue Damage and Improves Neurologic Function. J Clin Med. 2020;9(4):1221. Published 2020 Apr 23. doi:10.3390/jcm9041221


  1. Kwiecien JM, Dabrowski W, Marzec-Kotarska B, et al. Myxoma virus derived immune modulating proteins, M-T7 and Serp-1, reduce early inflammation after spinal cord injury in the rat model. Folia Neuropathol. 2019;57(1):41-50. doi:10.5114/fn.2019.83830

  2. Yaron JR, Kwiecien JM, Zhang L, et al. Modifying the Organ Matrix Pre-engraftment: A New Transplant Paradigm?. Trends Mol Med. 2019;25(7):626-639. doi:10.1016/j.molmed.2019.04.002

  3. Yaron JR, Chen H, Ambadapadi S, et al. Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice. J Inflamm (Lond). 2019;16:12. Published 2019 May 29. doi:10.1186/s12950-019-0215-1

  4. Zhang L, Yaron JR, Tafoya AM, et al. A Virus-Derived Immune Modulating Serpin Accelerates Wound Closure with Improved Collagen Remodeling. J Clin Med. 2019;8(10):1626. Published 2019 Oct 4. doi:10.3390/jcm8101626

  5. Feng Y, Han Z, Gu B, et al. A Novel Method for the Prevention and Treatment of Small-for-Size Syndrome in Liver Transplantation [published online ahead of print, 2020 Jan 31]. Dig Dis Sci. 2020;10.1007/s10620-020-06055-2. doi:10.1007/s10620-020-06055-2


  1. Shah C, Gong Y, Szady A, et al. Unanticipated Cardiotoxicity Associated with Targeted Anticancer Therapy in Patients with Hematologic Malignancies Patients: Natural History and Risk Factors. Cardiovasc Toxicol. 2018;18(2):184-191. doi:10.1007/s12012-017-9429-8

  2. Mahon BP, Ambadapadi S, Yaron JR, et al. Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function. Biochemistry. 2018;57(7):1096-1107. doi:10.1021/acs.biochem.7b01171

  3. Chen H, Ambadapadi S, Wakefield D, et al. Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection. Sci Rep. 2018;8(1):13433. Published 2018 Sep 7. doi:10.1038/s41598-018-31779-7

  4. Lucas A, Yaron JR, Zhang L, Ambadapadi S. Overview of Serpins and Their Roles in Biological Systems. Methods Mol Biol. 2018;1826:1-7. doi:10.1007/978-1-4939-8645-3_1

  5. Yaron JR, Ambadapadi S, Zhang L, Lucas A. Kinetic Measurement of Serpin Inhibitory Activity by Real-Time Fluorogenic Biochemical Assay. Methods Mol Biol. 2018;1826:65-71. doi:10.1007/978-1-4939-8645-3_4

  6. Zhang L, Yaron JR, Ambadapadi S, Lucas A. Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing. Methods Mol Biol. 2018;1826:133-142. doi:10.1007/978-1-4939-8645-3_9

  7. Chen H, Ambadapadi S, Dai E, et al. Analysis of In Vivo Serpin Functions in Models of Inflammatory Vascular Disease. Methods Mol Biol. 2018;1826:157-182. doi:10.1007/978-1-4939-8645-3_11

  8. Maldonado J, Yaron JR, Zhang L, Lucas A. Next-Generation Sequencing Library Preparation for 16S rRNA Microbiome Analysis After Serpin Treatment. Methods Mol Biol. 2018;1826:213-221. doi:10.1007/978-1-4939-8645-3_14

  9. Lucas A, Yaron JR, Zhang L, Macaulay C, McFadden G. Serpins: Development for Therapeutic Applications. Methods Mol Biol. 2018;1826:255-265. doi:10.1007/978-1-4939-8645-3_17

  10. Chen H, Bartee MY, Yaron JR, et al. Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR-/-) That Is Blocked by Interleukin-10. Viruses. 2018;10(10):518. Published 2018 Sep 23. doi:10.3390/v10100518

  11. Chukkapalli SS, Ambadapadi S, Varkoly K, et al. Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection. Pathog Dis. 2018;76(8):fty076. Published 2018 Nov 1. doi:10.1093/femspd/fty076


  1. Chukkapalli SS, Easwaran M, Rivera-Kweh MF, et al. Sequential colonization of periodontal pathogens in induction of periodontal disease and atherosclerosis in LDLRnull mice. Pathog Dis. 2017;75(1):ftx003. doi:10.1093/femspd/ftx003

  2. Kwiecien JM, Bassey-Archibong BI, Dabrowski W, Rayner LG, Lucas AR, Daniel JM. Loss of Kaiso expression in breast cancer cells prevents intra-vascular invasion in the lung and secondary metastasis. PLoS One. 2017;12(9):e0183883. Published 2017 Sep 7. doi:10.1371/journal.pone.0183883

  3. Al-Ani M, Ambadapadi S, Yaron JR, et al. Atrial Fibrillation Ablation Increases Inflammation-Chemokine Modulation Suppresses Activation of Leukocytes Isolated after Ablation. Cardiovasc Hematol Disord Drug Targets. 2017;17(3):195-204. doi:10.2174/1871529X17666170918140442


  1. Ambadapadi S, Munuswamy-Ramanujam G, Zheng D, et al. Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities. J Biol Chem. 2016;291(6):2874-2887. doi:10.1074/jbc.M115.704841


  1. Chukkapalli SS, Rivera-Kweh MF, Velsko IM, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L. Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers. Pathog Dis. 2015 Apr;73(3).

  2. Velsko IM, Chukkapalli SS, Rivera-Kweh MF, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L. Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory arkers with an Atheroprotective Immune Response in ApoEnull Mice. PLoS One. 2015;10(6):e0129795.

  3. Ildefonso CJ, Jaime H, Rahman MM, Li Q, Boye SE, Hauswirth WW, Lucas AR, McFadden G, Lewin AS. Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation. Hum Gene Ther. 2015 Jan;26(1):59-68.

  4. Chen H, Zheng D, Ambadapadi S, Davids J, Ryden S, Samy H, Bartee M, Sobel E, Dai E, Liu L, Macaulay C, Yachnis A, Weyand C, Thoburn R, Lucas A. Serpin treatment suppresses inflammatory vascular lesions in temporal artery implants (TAI) from patients with giant cell arteritis. PLoS One. 2015;10(2):e0115482.


  1. Brahn E, Lee S, Lucas A, McFadden G, Macaulay C. Suppression of collagen-induced arthritis with a serine proteinase inhibitor (serpin) derived from myxoma virus. Clin Immunol. 2014 Aug;153(2):254-63.

  2. Chukkapalli SS, Rivera MF, Velsko IM, Lee JY, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L. Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis. Infect Immun. 2014 May;82(5):1959-67.

  3. Lucas AR, Verma RK, Dai E, Liu L, Chen H, Kesavalu S, Rivera M, Velsko I, Ambadapadi S, Chukkapalli S, Kesavalu L. Myxomavirus anti-inflammatory chemokine binding protein reduces the increased plaque growth induced by chronic Porphyromonas gingivalis oral infection after balloon angioplasty aortic injury in mice. PLoS One. 2014;9(10):e111353.

  4. Zheng D, Chen H, Bartee MY, Williams J, Davids JA, Lomas DA, McFadden G, Lucas AR. Myxomaviral anti-inflammatory serpin reduces myeloid-derived suppressor cells and human pancreatic cancer cell growth in mice. Eur J Inflamm. 2014;12:131-45.

  5. Velsko IM, Chukkapalli SS, Rivera MF, Lee JY, Chen H, Zheng D, Bhattacharyya I, Gangula PR, Lucas AR, Kesavalu L. Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis. PLoS One. 2014 May 16;9(5):e97811.


  1. Chen H, Zheng D, Abbott J, Liu L, Bartee MY, Long M, Davids J, Williams J, Feldmann H, Strong J, Grau KR, Tibbetts S, Macaulay C, McFadden G, Thoburn R, Lomas DA, Spinale FG, Virgin HW, Lucas A. Myxomavirus-derived serpin prolongs survival and reduces inflammation and hemorrhage in an unrelated lethal mouse viral infection. Antimicrob Agents Chemother. 2013 Sep;57(9):4114-27.

  2. Zheng D, Chen H, Bartee MY, Williams J, Davids JA, Lomas DA, McFadden G, Lucas AR. Myxomaviral Anti-Inflammatory Serpin Reduces Myeloid-Derived Suppressor Cells and Human Pancreatic Cancer Cell Growth in Mice. J Cancer Sci Ther. 2013 Aug 19;5:291-299.

  3. Lucas A. Serpins as therapeutics--a potential biologic source for unique protein-based therapeutics. Cardiovasc Hematol Disord Drug Targets. 2013 Aug;13(2):89.

  4. Chen H, Davids JA, Zheng D, Bryant M, Bot I, van Berckel TJ, Biessen E, Pepine C, Ryman K, Progulski-Fox A, Kesavalu L, Moyer R, McFadden G, Lucas A. The serpin solution; targeting thrombotic and thrombolytic serine proteases in inflammation. Cardiovasc Hematol Disord Drug Targets. 2013 Aug;13(2):99-110.

  5. Zheng D, Chen H, Davids J, Bryant M, Lucas A. Serpins for diagnosis and therapy in cancer. Cardiovasc Hematol Disord Drug Targets. 2013 Aug;13(2):123-32.

  6. Rivera MF, Lee JY, Aneja M, Goswami V, Liu L, Velsko IM, Chukkapalli SS, Bhattacharyya I, Chen H, Lucas AR, Kesavalu LN. Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. PLoS One. 2013;8(2):e57178.