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(480)727-0798

Nobuyuki Matoba

Assistant Professor Research

The Biodesign Institute, Infectious Diseases and Vaccinology

Bio

Dr. Nobuyuki Matoba received his Ph.D. degree in Applied Life Science from Kyoto University, Japan in 2001. He was a JSPS Research Fellow (2000-2002) and was selected again for a JSPS Postdoctoral Fellow for Research Abroad (2004-2006). 

Since he came to ASU in July 2001, Dr. Matoba has been working on a project with Dr. Tsafrir Mor and Dr. Charles Arntzen to create a mucosal subunit vaccine designed to prevent mucosal transmission of HIV-1.

In conjunction with his previous five years of HIV vaccine research, Dr. Matoba is currently providing key leadership in new projects, including the development of new generation vaccines and microbicides against major human diseases that are posing serious global health concerns, with the main focus on HIV/AIDS. His projects are propelled by various technologies, including recombinant DNA, protein engineering, phage display and protein expression/production utilizing E. coli, insect and plant cells. Dr. Matoba’s research goal is to help improve human life in developing countries by bridging basic and applied sciences. 

Dr. Matoba’s research interests include: developing vaccines and microbicides against human diseases; searching for novel immunomodulators; and exploring various prokaryotic/eukaryotic recombinant expression systems.

Selected Publications

2006

  • Matoba, Nobuyuki, Geyer, B C, Kilbourne, J, Alfsen, A, Bomsel, M, Mor, Tsafrir S. Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR649-684, a mucosal subunit HIV/AIDS vaccine candidate. Vaccine (2006).
  • Matoba, Nobuyuki, Mor, T S. Plant-derived subunit vaccines. Plant Genetic Engineering vol. 7: Metabolic Engineering & Molecular pharming (2006).

2005

  • Matoba, Nobuyuki. Review of Plant-derived vaccines: an emerging technology towards the distribution of vaccines in developing countries Seibutsu-kogaku Kaishi 2005 2005. Review of Plant-derived vaccines: an emerging technology towards the distribution of vaccines in developing countries (2005).
  • Matoba, Nobuyuki, Arntzen, C J. Review of A current perspective on molecular farming in the USA Seibutsu-kogaku Kaishi 2005 2005 . Review of A current perspective on molecular farming in the USA (2005).

2004

  • Matoba, Nobuyuki, Magérus, A, Geyer, B C, Zhang, Y, Muralidharan, M, Alfsen, A, Arntzen, C J, Bomsel, M, Mor, T S. A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs. Proc. Natl. Acad. Sci. U.S.A (2004).
  • Onishi, K, Matoba, Nobuyuki, Yamada, Y, Doyama, N, Maruyama, N, Utsumi, S, Yoshikawa, M. Optimal designing of beta-conglycinin to genetically incorporate RPLKPW, a potent anti-hypertensive peptide. PEPTIDES (2004).

2003

  • Matoba, Nobuyuki, Yamada, Y, Yoshikawa, M. Review of Design of a genetically modified soybean protein preventing hypertension based on an anti-hypertensive peptide derived from ovalbumin Curr. Med. Chem.-Cardiovascular & Hematological Agen. Review of Design of a genetically modified soybean protein preventing hypertension based on an anti-hypertensive peptide derived from ovalbumin (2003).
  • Onishi, K, Matoba, Nobuyuki, Yamada, Y, Utsumi, S, Maruyama, N, Yoshikawa, M. Design of highly functional soybean protein by genetic introduction of anti-hypertensive peptide. Peptide Science 2002 (2003).

2002

  • Yamada, Y, Matoba, Nobuyuki, Usui, H, Onishi, K, Yoshikawa, M. Design of potent anti-hypertensive peptide based on ovokinin(2-7). Biosci. Biotechnol. Biochem (2002).

2001

  • Matoba, Nobuyuki, Doyama, N, Yamada, Y, Maruyama, N, Utsumi, S, Yoshikawa, M. Design and production of genetically modified soybean protein with anti-hypertensive activity by incorporating potent analogue of ovokinin(2-7). FEBS Lett (2001).
  • Matoba, Nobuyuki, Yamada, Y, Usui, H, Nakagiri, R, Yoshikawa, M. Designing potent derivatives of ovokinin(2-7), an anti-hypertensive peptide derived from ovalbumin. Biosci. Biotechnol. Biochem (2001).

2000

  • Yoshikawa, M, Fujita, H, Matoba, Nobuyuki, Takenaka, Y, Yamamoto, T, Yamauchi, R, Tsuruki, H, Takahata, K. Review of Bioactive peptides derived from food proteins preventing lifestyle-related diseases BioFactors 2000 2000 . Review of Bioactive peptides derived from food proteins preventing lifestyle-related diseases (2000).