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Biodesign Directory Profile

Contact Information

(480)727-9992

Kenneth Roland

Associate Research Professor

The Biodesign Institute, Infectious Diseases and Vaccinology

Selected Publications

2014

  • Pei, Y., V.R. Parreira, K.L. Roland, R. Curtiss III and J.F. Prescott. Assessment of attenuated Salmonella vaccine strains in controlling experimental Salmonella Typhimurium infection in broiler chickens. Can. J. Vet. Res (2014) Refereed Articles.

2013

  • Brenneman, K.E., C. Willingham, W. Kong, R. Curtiss III and K.L. Roland. Low pH rescue of acid-sensitive Salmonella Typhi strains by a rhamnose-regulated arginine decarboxylase system. Journal of Bacteriology (2013) Refereed Articles.
  • Mitra, A., A. Loh, A. Gonzales, P. Laniewski, C. Willingham, R. Curtiss III and K.L. Roland.. Safety and protective efficacy of live attenuated Salmonella Gallinarum vaccine candidates in Rhode Island Red chickens. Vaccine (2013) Refereed Articles.
  • Roland, K.L. and K.E. Brenneman. Salmonella as a vaccine delivery vehicle. Expert review of vaccines (2013) Refereed Articles.

2012

  • Brenneman, K.E., C. McDonald, S.M. Kelly-Aehle, K.L. Roland and R. Curtiss III. Use of the RapidChek SELECTTM Salmonella to detect shedding of live attenuated Salmonella enterica serovar Typhi vaccine strains. J. Microbiol. Meth. (2012) Refereed Articles.
  • Luo, Y., Q. Kong, J. Yang, A. Mitra, G. Golden, S-Y. Wanda, K.L. Roland, R.V. Jensen, P.B. Ernst and R. Curtiss III. Comparative genomic analysis of the high pathogenicity Salmonella Typhimurium strain UK-1. PLoS One (2012) Refereed Articles.
  • Sizemore, D.R., B. Warner, J. Lawrence, L.J. Thomas, K.L. Roland and K.P. Killeen. Construction and screening of attenuated ?phoP/Q Salmonella typhimurium vectored plague vaccine candidates.. Hum. Vaccin. Immunother. (2012) Refereed Articles.
  • Sizemore, D.R., B. Warner, J. Lawrence, L.J. Thomas, K.L. Roland and K.P. Killeen. Construction and screening of attenuated ?phoP/Q Salmonella typhimurium vectored plague vaccine candidates. Human Vaccines and Immunotherapeutics (2012) Refereed Articles.
  • Theoret, J.R., K.K. Cooper, B. Zekarias, K.L. Roland, B.F. Law, R. Curtiss III and L.A. Joens. The Campylobacter jejuni Dps homologue is important for in vitro biofilm formation and cecal colonization of poultry and may serve as a protective antigen for vaccination. Clin. Vaccine Immunol. (2012) Refereed Articles.

2011

  • Baek, C-H., H-Y. Kang, K.L. Roland and R. Curtiss III. Leucine-responsive regulatory protein (Lrp) acts as both a positive and negative regulator for type 1 fimbriae production in Salmonella enterica serovar Typhimurium. PLoS One (2011) Refereed Articles.
  • Kong, Q., D.A. Six, K.L. Roland, Q. Liu, L. Gu, C. M. Reynolds, X. Wang, C.R.H. Raetz, and R. Curtiss III. Salmonella synthesizing 1-dephosphorylated LPS exhibits low endotoxic activity while retaining its immunogenicity. J. Immunol. (2011) Refereed Articles.
  • Kong, Q., D.A. Six, Q. Liu, K.L. Roland, C.R.H. Raetz and R. Curtiss III. Palmitoylation state impacts the innate and acquired immunity of a Salmonella enterica serovar Typhimurium msbB mutant. Infect. Immun. (2011) Refereed Articles.
  • Kong, Q., J. Yang, Q. Liu, P. Alamuri, K.L. Roland and R. Curtiss III. Effect of deletion of genes involved in lipopolysaccharide core and O-antigen synthesis on virulence and immunogenicity of Salmonella enterica serovar Typhimurium. Infect. Immun. (2011) Refereed Articles.
  • Muralinath, M., M.J. Kuehn, K.L. Roland and R. Curtiss III. Immunization with Salmonella-derived outer membrane vesicles delivering the pneumococcal protein PspA confers protection against challenge with Streptococcus pneumoniae.. Infect. Immun (2011) Refereed Articles.
  • Muralinath, M., M.J. Kuehn, K.L. Roland and R. Curtiss III.. Immunization with Salmonella-derived outer membrane vesicles delivering the pneumococcal protein PspA confers protection against challenge with Streptococcus pneumoniae.. Infection and Immunity (2011) Refereed Articles.
  • Sun, W., D. Six, X. Kuang, K.L. Roland, C.R.H. Raetz, and R.Curtiss III. A live attenuated strain of Yersinia pestis as a vaccine against plague.. Vaccine (2011) Refereed Articles.
  • Sun, W., K.L. Roland and R. Curtiss III. Developing live vaccines against Yersinia pestis.. J. Infect. Dev. Ctries. (2011) Refereed Articles.
  • Wang, S. Y. Li, H. Shi, K.L. Roland and R. Curtiss III. Comparison of a regulated delayed antigen synthesis system with in vivo inducible promoters for antigen delivery by live attenuated Salmonella vaccines. Infect. Immun. (2011) Refereed Articles.
  • Wang, S. Y. Li, H. Shi, K.L. Roland and R. Curtiss III. Comparison of a regulated delayed antigen synthesis system with in vivo inducible promoters for antigen delivery by live attenuated Salmonella vaccines.. Infection and immunity (2011) Refereed Articles.
  • Zhang, X., S-Y. Wanda, K. Brenneman, W. Kong, X. Zhang, K.L. Roland and R. Curtiss III. Improving Salmonella vector with rec mutation to stabilize DNA cargoes. BMC Microbiol (2011) Refereed Articles.
  • Zhang, X., S-Y. Wanda, K. Brenneman, W. Kong, X. Zhang, K.L. Roland and R. Curtiss III. Improving Salmonella vector with rec mutation to stabilize DNA cargoes. BMC Microbiology (2011) Refereed Articles.

2010

  • Branger, C.G., W. Sun, A. Torres-Escobar, R. Perry, K.L. Roland, J. Fetherston, and R. Curtiss III.. Evaluation of Psn, HmuR and a modified LcrV protein delivered to mice by live attenuated Salmonella as a vaccine against bubonic and pneumonic plague.. Vaccine (2010) Refereed Articles.
  • Jiang, Y., R.R. Kulkarni, V.R. Parreira, C. Poppe, K.L. Roland and J.F. Prescott. Assessment of two Salmonella enterica serovar Typhimurium-based necrotic enteritis vaccines in reducing colonization of chickens by Salmonella serovars of different serogroups.. Can. J. Vet. Res (2010) Refereed Articles.
  • Roland, K.L., S. Tinge, S.K. Kochi, L.J. Thomas, and K.P. Killeen. Reactogenicity and immunogenicity of live attenuated Salmonella enterica serovar Paratyphi A enteric fever vaccine candidates. Vaccine (2010) Refereed Articles.
  • Roland, K.L., S. Tinge, S.K. Kochi, L.J. Thomas, and K.P. Killeen. Reactogenicity and immunogenicity of live attenuated Salmonella enterica serovar Paratyphi A enteric fever vaccine candidates.. Vaccine (2010) Refereed Articles.
  • Shi, H. J. Santander, K. Brenneman, S.-Y. Wanda, S. Wang, P. Senechal, W. Sun, K.L. Roland and R. Curtiss III.. Live recombinant Salmonella Typhi vaccines constructed to investigate the role of rpoS in eliciting immunity to a heterologous antigen.. PLoS One (2010) Refereed Articles.
  • Shi, H., S. Wang, K.L. Roland, B. M. Gunn and R. Curtiss III. Evaluation of safety and immunogenicity of a live recombinant Salmonella vaccine expressing pspA in neonates and infant mice born from na?ve and immunized mothers.. Clin. Vaccine Immunol. (2010) Refereed Articles.
  • Shi, H., S. Wang, K.L. Roland, B. M. Gunn and R. Curtiss III. Evaluation of safety and immunogenicity of a live recombinant Salmonella vaccine expressing pspA in neonates and infant mice born from na?ve and immunized mothers.. Clin. Vaccine Immunol (2010) Refereed Articles.
  • Sun, W., K.L. Roland, C.G. Branger, X. Kuang and R. Curtiss III. Yersinia pestis crp mutants that are attenuated and induce protective immunity against plague. Infect. Immun. (2010) Refereed Articles.
  • Wang, S., Y. Li, G. Scarpellini, W. Kong, H. Shi, C-H. Baek, B. Gunn, S-Y. Wanda, K.L. Roland, X. Zhang, P. Senechal-Willis and R. Curtiss III.. Salmonella vaccine vectors displaying delayed antigen synthesis in vivo to enhance immunogenicity.. Infection and Immunity (2010) Refereed Articles.
  • Wang, S., Y. Li, H. Shi, G. Scarpellini, A. Torres-Escobar, K.L. Roland, and Roy Curtiss III.. Immune responses to recombinant pneumococcal PsaA antigen delivered by live attenuated Salmonella vaccine.. Infection and Immunity (2010) Refereed Articles.

2009

  • Baek, C-H., S. Wang, K. L. Roland, and R. Curtiss III. Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium.. J. Bacteriol (2009) Refereed Articles.
  • Branger, C.G., A. Torres-Escobar, W. Sun, R. D. Perry, J. D. Fetherston, K. L. Roland and R. Curtiss III. Oral vaccination with LcrV from Yersinia pestis KIM delivered by live attenuated Salmonella enterica serovar Typhimurium elicits a protective immune response against challenge with Yersinia pseudotuberculosis and Yersinia enterocolitica.. Vaccine (2009) Refereed Articles.
  • Kong, Q., Q. Liu, K.L. Roland and R. Curtiss III. Regulated delayed expression of rfaH in an attenuated Salmonella vaccine enhances immunogenicity of outer membrane proteins and a heterologous antigen. Infect. Immun. (2009) Refereed Articles.
  • Li, Y., S. Wang, G. Scarpellini, B. Gunn, W. Xin, S.-Y. Wanda, K.L. Roland and R. Curtiss III. Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA. Proc. Natl. Acad. Sci. USA. . (2009) Refereed Articles.
  • Sun, W., K.L. Roland, C.G. Branger, X. Kuang and R. Curtiss III. The role of relA and spoT in Yersinia pestis KIM5+ pathogenicity.. PLoS One (2009) Refereed Articles.
  • Xin, W., Y. Li, H. Mo, K. L. Roland and R. Curtiss, III. PspA family fusion proteins delivered by attenuated Salmonella enterica serovar Typhimurium extend and enhance protection against Streptococcus pneumoniae.. Infect. Immun. (2009) Refereed Articles.