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Contact Information

(480)727-8570

Hao Yan, PhD

Professor

The Biodesign Institute, Single Molecule Biophysics

Professor

College of Liberal Arts and Sciences, Chemistry and Biochemistry

Bio

Visit the Yan lab website.

Professor, Department of Chemistry and Biochemistry, College of Liberal Arts and Sciences

Office: BDA-124B, Lab: BDA-131
Phone: 480-727-8570, Lab: 480-727-0428
Fax: 480-965-2747

Education

Ph.D., New York University, 2001

Research Areas

Biochemistry, analytical chemistry, inorganic and materials chemistry

Research and Teaching Interests

Hao Yan's research program is highly interdisciplinary which combines chemistry, biology, physics and material science. The goal of his research group is to achieve programmed design and assembly of biologically inspired nanomaterials and to explore its applications in nanoelectronics, controlled macromolecular interactions and biosensing. Their research is focused in the following four themes:

1) Bio-Nanotechnology: Design of novel DNA nanostructures, implementation of the designed structure in the construction of patterned DNA arrays and nanomechanical devices. Develop modular methods to achieve biomimetic molecular motors.

2) Nanoelectronics: Utilize rationally designed DNA nanostructure to template nanoelectronic components such as nanoparticles or carbon nanotubes into functional nanodevices.

3) Macromolecule Structure Elucidation: Develop methods to self-assemble 2-D and 3-D protein arrays for structural determination using Electron Microscopy or X-ray Crystallography.

4) Biomolecular Imaging: Investigation of protein-DNA interactions using high resolution imaging technology such as Atomic Force Microscopy and Electron Microscopy.

Major techniques in the group include: DNA/RNA/Protein manipulation (gel electrophoresis, labeling, hybridization, PCR and footprinting, cloning), electron-beam lithography, Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Electron Microscopy (EM), Fluorescence Spectroscopy, UV-Vis, Circular Dichroism (CD) and chemical synthesis.

Selected Publications

1. "Quantum Dots Bioconjugation During Core-Shell Synthesis," Q. Wang, Y. Liu, Y. Ke, H. Yan, Angew Chem Int Ed. 47, 316-319 (2008).

2. "Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays," Yonggang Ke, Stuart Lindsay, Yung Chang, Yan Liu, Hao Yan*, Science 319, 180-183 (2008).

3. "DNA-Tile-Directed Self-assembly of Quantum Dots into Two-Dimensional Nanopatterns," J. Sharma, Y. Ke, C. Lin, R. Chhabra, Q. Wang, J. Nangreave, Y. Liu, H. Yan, Angew Chem Int Ed 47, 5157-5159 (2008).

4. "Toward Reliable Gold Nanoparticle Patterning on Self-assembled DNA Nanoscaffold," J. Sharma, R. Chhabra, C. Anderson, K. Gothelf, H. Yan, Y. Liu, J. Am. Chem. Soc. 130, 7820-7821 (2008).

5. "Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein binding," S. Rinker, Y. Ke, Y. Liu*, R. Chhabra, H. Yan*, Nature Nanotechnology 3, 418-422 (2008).

Selected Publications

2008

  • Chhabra, R, Sharma, J, Liu, Yan, Yan, Hao. DNA Self-Assembly for Nanomedicine. Advanced Drug Delivery (2008).
  • Ding, B, Liu, Yan, Rinker, S, Yan, Hao. DNA-Templated Self-assembly of Protein Arrays and Highly Conductive Nanowires. Encyclopedia of Complexity and System Science (2008).
  • Ke, Y., Lindsay, S., Chang, Y., Liu, Y., Yan, Hao. Self-assembled Water-soluble Nucleic Acid Probe Tiles for Label Free RNA Detection. Science (2008).
  • Wang, Q., Liu, Y., Ke, Y., Yan, Hao. Quantum Dots Bioconjugation During Core-Shell Synthesis. Angew. Chem. Int. Ed. (2008).
  • Wang, Q., Liu, Yan, Ke, Y, Yan, Hao. Quantum Dot Bioconjugation during Core-Shell Synthesis. Angew. Chem. Int. Ed (2008).

2007

  • Chhabra, R, Sharma, J, Liu, Yan, Yan, Hao. Patterning Metallic Nanoparticles by DNA Scaffolds. Biological Studies and Applications of Engineered Nanostructures (2007).
  • Chhabra, R., Sharma, J., Ke, Y., Liu, Y., Rinker, S., Lindsay, S., Yan, Hao. Spatially Addressable Multi-protein Nanoarrays Templated by Aptamer Tagged DNA Nanoarchitectures. J. Am. Chem. Soc. (2007).
  • Chhabra, R., Sharma, J., Liu, Y., Yan, Hao. Bio-Applications of Nanoparticles Landes Bioscience 2007 2007 . Bio-Applications of Nanoparticles (2007).
  • Lin, C, Liu, Y, Yan, Hao. Self-assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing. Nano Letters (2007).
  • Lin, C., Liu, Y., Mertig, M., Gu, J., Yan, Hao. Functional DNA Nanotube Arrays: Bottom-up Meets Top-down. Angew. Chem. Int. Ed. (2007).
  • Lin, C., Liu, Yan, Yan, Hao. Self-assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing. Nano Lett (2007).
  • Lin, C., Wang, X., Liu, Y., Seeman, N., Yan, Hao. Rolling Circle Enzymatic Replication of a Complex Multi-crossover DNA Nanostructure. J. Am. Chem. Soc. (2007).
  • Sharma, J, Chhabra, R, Yan, Hao, Liu, Y. pH-driven Conformational Switch of "i-motif" DNA for Reversible Assembly of Gold Nanoparticles. Chemical Communication (2007).
  • Wang, Q, Liu, Y, Yan, Hao. Lay-by-layer Growth of Superparamagnetic and fluorecently barcoded Nanospheres. Nanotechnology (2007).
  • Wang, Q., Liu, Y., Yan, Hao. Mechanism of a Self-templating Synthesis of Monodispersed Hollow Silica Nanospheres with Tunable Size and Shell Thickness. Chemical Communication (2007).
  • Wang, Q., Xu, Y., Zhao, X., Chang, Y., Liu, Y., Jiang, L., Sharma, J., Seo, D. , Yan, Hao. A Facile One-step In situ Functionalization of Quantum Dots with Preserved Photoluminescence for Bioconjugation. J. Am. Chem. Soc. (2007).
  • Williams, B, Lund, K, Liu, Y, Yan, Hao, Chaput, J. Self-assembled Peptide Nanoarrays: A new approach to studying protein-protein interactions. Angew Chem It Ed (2007).

2006

  • Chhabra, R, Sharma, J, Liu, Yan, Yan, Hao. Addressable Molecular Tweezers for DNA templated coupling reactions. Nano Lett (2006).
  • J Zhang, Y, Liu, Yan, Yan, Hao. Periodic Square-like gold nanoparticle arrays templated by a DNA nanogrids on a surface. Nano Lett (2006).
  • Ke, Y, Liu, Yan, Zhang, J, Yan, Hao. A Study of DNA tube formation mechanisms using 4-, 8- and 12-helix DNA nanostructures. J. Am. Chem. Soc (2006).
  • Lin, C, Katilius, E, Liu, Yan, Yan, Hao. Self-assembled Signaling Aptamer Nanoarrays for Protein Detection. Angew. Chem. Int. Ed (2006).
  • Lin, C, Liu, Yan, Rinker, S, Yan, Hao. DNA tile Based Self-assembly: Building Complex Nano-architectures. ChemPhysChem (2006).
  • Lin, C, Xie, M, Chen, J, Liu, Y, Yan, Hao. Rolling Circle Amplification of a DNA Nano- junction. Angew. Chem. Int. Ed (2006).
  • Lin, C, Xie, M, Chen, J, Liu, Y, Yan, Hao. Rolling Circle Amplification of a DNA Nano-junction. Angew. Chem. Int. Ed (2006).
  • Lin, L, Wang, H, Liu, Yan, Yan, Hao, Lindsay, S. Recognition imaging with a DNA aptamer. Biophysical J (2006).
  • Lund, K, Liu, Yan, Yan, Hao. Combinatorial Self-assembly of DNA Nanostructures. Organic and Biomolecular Chemistry (2006).
  • Lund, K, Williams, B, Ke, Y G, Liu, Yan, Yan, Hao. DNA nanotechnology: a rapidly evolving field. Current Nanoscience (2006).
  • Rinker, S, Liu, Y, Yan, Hao. Two Dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex. Chemical Communication (2006).
  • Sharma, J, Chhabra, R, Liu, Yan, Ke, Y, Yan, Hao. DNA templated self-assembly of two-dimensional and periodical gold nanoparticle arrays. Angew. Chem. Int. Ed (2006).
  • Yan, Hao, Xu, B. Towards Rapid DNA Sequencing: Detecting Single-Stranded DNA with a Solid-State Nanopore. Small (2006).
  • Yan, Hao, Yan, Liu. DNA nanotechnology: an evolving field. Nanotechnology: Science and Computation (2006).

2005

  • Liu, Yan, Ke, Y, Yan, Hao. Self-assembly of symmetric finite size DNA nanoarrays. J. Am. Chem. Soc (2005).
  • Liu, Yan, Lin, C X, Li, H, Yan, Hao. Aptamer directed Self-assembly of Proteins on a DNA Nanostructure. Angew. Chem. Int. Ed (2005).
  • Liu, Yan, Yan, Hao. Modular Self-assembly of DNA Lattice with Tunable Periodicity. Small (2005).
  • Lund, K, Liu, Yan, Lindsay, S, Yan, Hao. Self-assembling Molecular Pegboard. J. Am. Chem. Soc (2005).
  • Park, S H, Barish, R, Li, H, Reif, J H, Finkelstein, G, Yan, Hao, LaBean, T H. Three Helix Bundle DNA Tiles Self-assemble into 2D Lattice or 1D Templates for Silver Nanowires. Nano Lett (2005).
  • Park, S H, Yin, P, Liu, Yan, Reif, J, LaBean, T H, Yan, Hao. Programmable DNA Self-assemblies for Nanoscale Organization of Ligands and Proteins. Nano Lett (2005).
  • Reif, J H, LaBean, T H, Sahu, S, Yan, Hao, Yin, P. Design, Simulation, and Experimental Demonstration of Self-assembled DNA Nanostructures and Motors. UPP2004, LNCS 3566 (2005).
  • Seeman, N C, Ding, B, Liao, S, Wang, T, Sherman, W B, Constantinou, P E, Kopatsch, J, Mao, C, Sha, R, Liu, F, Yan, Hao, Lukeman, P S. Experiments in Structural DNA Nanotechnology: Arrays and Devices. Proc. SPIE; Nanofabrication: Technologies, Devices and Applications (2005).
  • Sha, R, Zhang, X, Liao, S, Constantinou, P E, Ding, B, Wang, T, Garibotti, A V, Zhong, H, Israel, L B, Wang, X, Wu, G, Chakraborty, B, Chen, J, Zhang, Y, Mao, C, Yan, Hao, Kopatsch, J, Zheng, J, Lukeman, P S, Sherman, W B, Seeman, N C. Motifs and Methods in Structural DNA Nanotechnology. Proc. Intl. Conf. Nanomaterials (2005).
  • Sha, R, Zhang, X, Liao, S, Constantinou, P, Ding, B, Wang, T, Garibotti, A V, Zhong, H, Israel, L B, Wang, X, Wu, G, Chakraborty, B, Chen, J, Zhang, Y, Yan, Hao, Shen, Z, SHen, W, Sa-Ardyen, P, Kopatsch, J, Zheng, J, Lukeman, P, Sherman, W B, Mao, C, Jono. Structural DNA Nanotechnology: Molecular Construction and Composition. UC2005, LNCS 3699 (2005).
  • Yan, Hao. Computing with Nucleic Acids. Bioelectronics (2005).
  • Yan, Hao, Liu, Yan. DNA Nanotechnology: An Evolving Field. Nanotechnology: Science and Computation (2005).

2004

  • Li, Hanying, Ha Park, Sung, Reif, John H, LaBean, Thomas H, Yan, Hao. DNA templated self-assembly of protein and nanoparticle linear arrays. J. Am. Chem. Soc (2004).
  • Park, S H, Yan, Hao, Reif, J H, LaBean, T H, Finkelstein, G. Electronic nanostructures templated on self-assembled DNA scaffolds. Nanotechnology (2004).
  • Peng, Yin, Yan, Hao, Guan, XiaoJu, Turberfield, Andrew J, Reif, John H. An autonomous Unidirectional DNA walker. Angew. Chem. Int. Ed (2004).
  • Shen, Zhiyong, Yan, Hao, Wang, Tong, Seeman, Nadrian C. Paranemic Crossover DNA: A Generalized Holliday Structure with Applications in Nanotechnology. J. Am. Chem. Soc (2004).
  • Yan, Hao. Nucleic Acid Nanotechnology. Science (2004).
  • Yan, Hao. Nucleic Acid Nanotechnology. Science (2004).
  • Yan, Hao, Yin, P, Park, S H, Li, H, Feng, L, Guan, X, Liu, D, Reif, J H, LaBean, T H. Self-assembled DNA structures for nanoconstruction. AIP Conference Proceedings (DNA-Based Molecular Electronics) (2004).

2003

  • Feng, L, Park, S H, Reif, J H, Yan, Hao. A two-state DNA lattice switched by DNA nanoactuator. Angew. Chem. Int. Ed (2003).
  • Yan, Hao, Feng, L, LaBean, T H, Reif, J H. Parallel Molecular Computation of Pair-wise Exclusive-Or (XOR) using DNA "String Tile" Self-Assembly. J. Am. Chem. Soc (2003).
  • Yan, Hao, LaBean, T H, Feng, L, Reif, J H. Directed Nucleation Assembly of DNA tile Complexes for Barcode Patterned Lattices. Proc. Natl. Acad. Sci. U.S.A (2003).
  • Yan, Hao, Park, S H, Finkelstein, G, Reif, J H, LaBean, T H. DNA templated Self-assembly of Protein Arrays and Highly Conductive Nanowires. Science (2003).
  • Yan, Hao, Seeman, N C. Edge-sharing DNA triangles and One-dimensional self-assembly. J. Supramol. Chem (2003).

2002

  • Seeman, N C, Yan, Hao, Zhang, X. A robust sequence-dependent rotary DNA nanomechanical device controlled by hybridization topology. Biophys. J (2002).
  • Yan, Hao, Yang, X, Shen, Z, Seeman, N C. A Robust Sequence-dependent Rotary DNA Device. Nature (2002).
  • Zhang, X, Yan, Hao, Shen, Z, Seeman, N C. Paranemic Cohesion of Topologically-Closed DNA Molecules. J. Am. Chem. Soc (2002).

2000

  • LaBean, T H, Yan, Hao, Kopatsch, J, Liu, F, Winfree, E, Reif, J H, Seeman, N C. The Construction, analysis, ligation and self-assembly of DNA Triple Crossover Molecules. J. Am. Chem. Soc (2000).
  • Seeman, N C, Mao, C, Liu, F, Sha, R, Yang, X, Wenzler, L, Li, X, Shen, Z, Yan, Hao, Sa-Ardyen, P, Zhang, X, Shen, W, Birac, J, Lukeman, P, Pinto, Y, Qi, J, Liu, B, Qiu, H, Du, S M, Wang, H, Sun, W, Wang, Y, Fu, T -J, Zhang, Y, Mueller, J E, Chen, J. Nicks, Nodes, and New Motifs for DNA Nanotechnology. Frontiers of Nano-Optoelectronic Systems (2000).