The Center for Ecogenomics in the Biodesign Institute at Arizona State University has an immediate opening for a scientist with extensive expertise in biological confocal scanning light microscopy. We conduct life-sciences based research into cellular physiology and disease on both mammalian cells and microbes. The successful candidate will work in a multidisciplinary team environment serving as the point person for research involving two state of the art imaging systems (and several additional transmitted and fluorescence microscopes): 1) A Nikon multi-mode confocal microscope system consisting of a LiveScan SFC (swept field confocal), Spectral C1si (high-spectral resolution) confocal, and Perfect Focus TE2000E2 inverted microscope with TIRF accessories; and 2) A novel cell CT scanner for direct 3D absorption and fluorescence imaging of single cells.
At the core of the skill set we seek is the high level of expertise in fluorescent probe selection and labeling technologies and protocols—and associated probe excitation and emission considerations—necessary to provide optimal signal to noise ratios and to achieve novel and ambitious scientific objectives. This is a hands-on position requiring daily involvement in specimen preparation and image data acquisition in addition to a thorough understanding of the experimental goals and design. The successful candidate will assume full responsibility for managing and optimizing the Center’s imaging facility, providing training and expert input to users and active involvement in planning, design and execution of complex research studies. The successful candidate will be expected to keep current with published literature and new developments and technologies that will advance the mission of the center. Opportunities exist to pursue own research interests.
PhD in cell or molecular biology or related field, and a minimum of five years of recent, hands-on experience in all aspects of biological fluorescence confocal laser scanning microscopy: cell culture; probe selection or design; cell labeling including immunocytochemical labeling and fluorescence in situ hybridization; and image acquisition. Extensive expertise in molecular biology and cell labeling is essential.
Demonstrated track record of high-quality publications and extramural funding; hands-on experience in all aspects of absorption light microscopy including immunoperoxidase staining; proficiency in slide- and tube-based cell preparation and staining protocols and in 3D confocal imaging and image rendering is highly desirable. Demonstrated expertise in image processing and analysis; mathematics and practical aspects of image reconstruction from projections; other microscopies (various LM modes; TEM; scanned probe; x-ray); molecular biological methods (PCR, FACS, laser capture microdissection); histological techniques; cancer biopsy processing; statistics and design of experiments is preferred but not required.
Deadline: September 18, 2009; then every week thereafter until the search is closed.
Submit curriculum vitae (CV) plus cover letter addressed to: Roger Johnson, Ph.D, Biodesign Institute via email: roger.h.johnson@asu.edu. Please reference “Associate Research Scientist (Confocal Microscopist)” in the subject line. Candidates invited to interview will be asked to provide the names, addresses (e-mail and/or street) and telephone numbers for three (3) professional references.
The Biodesign Institute at Arizona State University is focused on innovations that improve healthcare; provide renewable sources of energy and clean our environment; outpace the global threat of infectious disease; and enhance national security. Using a team approach that converges the biosciences with nanoscale engineering and advanced computing; the goal is to find solutions to complex global challenges and accelerate these discoveries to market. The institute also educates future scientists by providing hands-on laboratory research for more than 200 students each semester. More information about the Biodesign Institute may be found at: http://www.biodesign.asu.edu.
This position is a year-to-year appointment. Continuation of this position is contingent on satisfactory performance, availability of funding and the needs of the program. Pre-employment screening, including a criminal history background check of the finalist is required under Arizona Board of Regents policy. AA/EOE.
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